Epigenetics | The Chen Lab

New paper in Nature Communications

Thu, 19 Mar 2026 00:00:00 +0000

We are excited to share that our paper “Polycomb Repressive-Deubiquitinase Complex Safeguards Oocyte Epigenome and Female Fertility by Restraining Polycomb Activity” has been published in Nature Communications.

Congratulations to JW Kang and the entire team for this work!

Polycomb Repressive-Deubiquitinase Complex Safeguards Oocyte Epigenome and Female Fertility by Restraining Polycomb Activity

Thu, 01 Jan 2026 00:00:00 +0000

CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos

Mon, 14 Nov 2022 00:00:00 +0000

Cell type-specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis

Tue, 01 Mar 2022 00:00:00 +0000

Distinct dynamics and functions of H2AK119ub1 and H3K27me3 in mouse preimplantation embryos

Thu, 01 Apr 2021 00:00:00 +0000

Maternal H3K27me3-dependent autosomal and X chromosome imprinting

Tue, 01 Sep 2020 00:00:00 +0000

Allelic H3K27me3 to allelic DNA methylation switch maintains noncanonical imprinting in extraembryonic cells

Sun, 01 Dec 2019 00:00:00 +0000