Epigenetics

New paper in Nature Communications

Our study on Polycomb Repressive-Deubiquitinase Complex in oocyte epigenome is now published in Nature Communications.

Last updated on Apr 7, 2026 1 min read

Polycomb Repressive-Deubiquitinase Complex Safeguards Oocyte Epigenome and Female Fertility by Restraining Polycomb Activity

Kang J, Liu P, Ichimura S, Cook L, Hu M, Namekawa SH, Chen Z*

CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos

Wang M*, Chen Z*, Zhang Y

Cell type-specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis

Chen R, Liu Y, Djekidel MN, Chen W, Bhattacherjee A, Chen Z, Scolnick E, Zhang Y

Distinct dynamics and functions of H2AK119ub1 and H3K27me3 in mouse preimplantation embryos

Chen Z*, Djekidel MN*, Zhang Y

Maternal H3K27me3-dependent autosomal and X chromosome imprinting

Chen Z, Zhang Y

Allelic H3K27me3 to allelic DNA methylation switch maintains noncanonical imprinting in extraembryonic cells

Chen Z, Yin Q, Inoue A, Zhang C, Zhang Y