Publications

Since 2023 (Independent Lab)

Zhou C, Wang M, Chen Z, Zhang Y (2026). Decoding the cell intrinsic and extrinsic roles of PRC2 in early embryogenesis. bioRxiv.

Kang J, Liu P, Ichimura S, Cook L, Hu M, Namekawa SH, Chen Z* (2026). Polycomb Repressive-Deubiquitinase Complex Safeguards Oocyte Epigenome and Female Fertility by Restraining Polycomb Activity. Nature Communications. In press..

Kang J, Liu P, Ichimura S, Cook L, Chen Z* (2025). Polycomb Repressive-Deubiquitinase Complex Safeguards Oocyte Epigenome and Female Fertility by Restraining Polycomb Activity. bioRxiv.

Chen Z*, Zhang C*, Zhang Y (2025). Chromatin Analyses in Mouse Oocytes and Preimplantation Embryos. Methods in Molecular Biology.

Yang J, Cook L, Chen Z* (2024). Systematic evaluation of retroviral LTRs as cis-regulatory elements in mouse embryos. Cell Reports.

Yang J, Cook L, Chen Z* (2023). Systematic perturbation of thousands of retroviral LTRs in mouse embryos. bioRxiv.

Before 2023

Wang M*, Chen Z*, Zhang Y (2022). CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos. The EMBO Journal, 41(22):e112012.

Chen R, Liu Y, Djekidel MN, Chen W, Bhattacherjee A, Chen Z, Scolnick E, Zhang Y (2022). Cell type-specific mechanism of Setd1a heterozygosity in schizophrenia pathogenesis. Science Advances, 8(9):eabm1077.

Chen Z, Xie Z, Zhang Y (2021). DPPA2 and DPPA4 are dispensable for mouse zygotic genome activation and pre-implantation development. Development, 148(24):dev200178.

Chen Z*, Djekidel MN*, Zhang Y (2021). Distinct dynamics and functions of H2AK119ub1 and H3K27me3 in mouse preimplantation embryos. Nature Genetics, 53(4):551-563.

Chen Z, Zhang Y (2020). Maternal H3K27me3-dependent autosomal and X chromosome imprinting. Nature Reviews Genetics, 21(9):555-571.

Chen Z, Zhang Y (2020). Role of mammalian DNA methyltransferases in development. Annual Review of Biochemistry, 89(1):135-158.

Zhang C*, Chen Z*, Yin Q, Fu X, Li Y, Stopka T, Skoultchi AI, Zhang Y (2020). The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression. Genes & Development, 34(3-4):166-178.

Chen Z, Yin Q, Inoue A, Zhang C, Zhang Y (2019). Allelic H3K27me3 to allelic DNA methylation switch maintains noncanonical imprinting in extraembryonic cells. Science Advances, 5(12):eaay7246.

Chen Z, Zhang Y (2019). Loss of DUX causes minor defects in zygotic genome activation and is compatible with mouse development. Nature Genetics, 51(6):947-951.

Zhang W*, Chen Z*, Yin Q, Zhang D, Racowsky C, Zhang Y (2019). Maternal-biased H3K27me3 correlates with paternal-specific gene expression in the human morula. Genes & Development, 33(7-8):382-387.

Inoue A*, Chen Z*, Yin Q, Zhang Y (2018). Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells. Genes & Development, 32(23-24):1525-1536.

Chen Z, Hagen DE, Ji T, Elsik CG, Rivera RM (2017). Global misregulation of genes largely uncoupled to DNA methylome epimutations characterizes a congenital overgrowth syndrome. Scientific Reports, 7(1):1-14.

Siqueira LG, Tribulo P, Chen Z, Denicol AC, Ortega MS, Negrón-Pérez VM, Kannampuzha-Francis J, Pohler KG, Rivera RM, Hansen PJ (2017). Colony-stimulating factor 2 acts from days 5 to 7 of development to modify programming of the bovine conceptus at day 86 of gestation. Biology of Reproduction, 96(4):743-757.

Chen Z, Hagen DE, Wang J, Elsik CG, Ji T, Siqueira LG, Hansen PJ, Rivera RM (2016). Global assessment of imprinted gene expression in the bovine conceptus by next generation sequencing. Epigenetics, 11(7):501-516.

Chen Z, Hagen DE, Elsik CG, Ji T, Morris CJ, Moon LE, Rivera RM (2015). Characterization of global loss of imprinting in fetal overgrowth syndrome induced by assisted reproduction. PNAS, 112(15):4618-4623.

Chen Z, Robbins KM, Wells KD, Rivera RM (2013). Large offspring syndrome: a bovine model for the human loss-of-imprinting overgrowth syndrome Beckwith-Wiedemann. Epigenetics, 8(6):591-601.

Robbins KM, Chen Z, Wells KD, Rivera RM (2012). Expression of KCNQ1OT1, CDKN1C, H19, and PLAGL1 and the methylation patterns at the KvDMR1 and H19/IGF2 imprinting control regions is conserved between human and bovine. Journal of Biomedical Science, 19(1):1-10.