News | The Chen Lab

Jinwen presents at Developmental Biology divisional meeting

Mon, 30 Mar 2026 00:00:00 +0000

Jinwen gave a talk in the weekly Developmental Biology divisional meeting on the exciting PR-DUB story.

New paper in Nature Communications

Thu, 19 Mar 2026 00:00:00 +0000

We are excited to share that our paper “Polycomb Repressive-Deubiquitinase Complex Safeguards Oocyte Epigenome and Female Fertility by Restraining Polycomb Activity” has been published in Nature Communications.

Congratulations to JW Kang and the entire team for this work!

Jinwen receives Lalor Foundation Fellowship

Fri, 13 Mar 2026 00:00:00 +0000

Jinwen received The Lalor Foundation fellowship to support his research in understanding PR-DUB function in female fertility! Big congratulations!

ZY speaks at Maternal-to-Zygotic Transition Symposium

Thu, 19 Feb 2026 00:00:00 +0000

ZY gave a talk at the Maternal-to-Zygotic Transition (MZT) virtual symposium!

ZY Chen receives SSR Rising Star Award

Thu, 12 Feb 2026 00:00:00 +0000

ZY is honored to give a seminar in 2026 SSR Rising Stars Webinar!

Jinwen presents at SDB Midwest Regional Meeting

Fri, 19 Sep 2025 00:00:00 +0000

Jinwen shared recent progress on PR-DUB complex at the SDB Midwest Regional Meeting.

Welcome Shuai Sun to the lab!

Mon, 15 Sep 2025 00:00:00 +0000

Welcome Shuai Sun (Ph.D.) to our lab as a research fellow!

Lab presents at SSR Annual Conference

Mon, 04 Aug 2025 00:00:00 +0000

The lab presented recent work at the Society for the Study of Reproduction annual conference in Washington DC.

Lab receives 5-year NIH R01 award

Thu, 05 Jun 2025 00:00:00 +0000

We are thrilled to receive a 5-year NIH R01 award to support research on understanding the gene regulatory roles of long terminal repeat (LTR) retrotransposons in mouse early development using (epi)genome editing and multi-omics analyses.

New protocol published on chromatin analyses during ZGA

Wed, 28 May 2025 00:00:00 +0000

We contributed a protocol on chromatin analyses during Zygotic Genome Activation in mouse embryos. Cheers!

Welcome Natalie Pfaltzgraff!

Mon, 12 May 2025 00:00:00 +0000

Welcome Natalie Pfaltzgraff to our lab as a rotation student!

ZY presents at Developmental Biology divisional meeting

Mon, 31 Mar 2025 00:00:00 +0000

ZY presented on a new research finding at the Developmental Biology divisional meeting.

ZY gives talk at University of Missouri

Wed, 05 Feb 2025 00:00:00 +0000

ZY was honored to give a talk at the University of Missouri, Columbia! Proud to be a Mizzou alumni—Go Tigers!

Lab welcomes new members and celebrates Chinese New Year

Fri, 24 Jan 2025 00:00:00 +0000

Lab welcomed Shoko and Jinwen, celebrated Lauryn’ and Peiyao’s graduate school offers, and observed Chinese New Year.

Welcome Jinwen Kang to the lab!

Mon, 25 Nov 2024 00:00:00 +0000

Welcome Jinwen Kang (Ph.D.) to our lab as a research fellow!

Welcome Peiyao Liu!

Tue, 26 Mar 2024 00:00:00 +0000

Welcome Peiyao Liu to our lab!

Jian presents at divisional meeting

Mon, 25 Mar 2024 00:00:00 +0000

Jian gave a very nice talk on his research in the weekly divisional meeting. Congratulations! Keep up the good work!

Welcome Neha Gupta!

Mon, 04 Mar 2024 00:00:00 +0000

Welcome Neha Gupta to our lab!

New paper in Cell Reports

Tue, 20 Feb 2024 00:00:00 +0000

Our systematic evaluation of retroviral LTRs as cis-regulatory elements in mouse embryos was published in Cell Reports.

ZY delivers CCRF seminar

Wed, 31 Jan 2024 00:00:00 +0000

ZY gave a seminar titled “Decoding chromatin reprogramming and retrotransposon activation when life begins” at the CCRF DB seminar series.

First Chen Lab paper accepted!

Thu, 11 Jan 2024 00:00:00 +0000

Celebration of the first Chen lab paper “in principle” acceptance! Cheers!

Lab holiday celebration

Fri, 22 Dec 2023 00:00:00 +0000

Lab gathered for holiday festivities.

Lab receives CCHMC Trustee Award

Tue, 12 Dec 2023 00:00:00 +0000

We are excited to receive the Trustee Award ($200k over two years) from Cincinnati Children’s Research Foundation for studying retrotransposon function in mammalian early development.

ZY presents at CCHMC Regulatory Genomics Forum

Wed, 11 Oct 2023 00:00:00 +0000

ZY presented “Systematic perturbation of thousands of retroviral LTRs” at the CCHMC Regulatory Genomics forum.

Welcome Dr. Jian Yang!

Mon, 31 Jul 2023 00:00:00 +0000

Welcome Dr. Jian Yang to our lab!

Welcome Lauryn Cook!

Mon, 05 Jun 2023 00:00:00 +0000

Welcome Lauryn Cook to our lab!! The Chen lab is growing!

ZY speaks at Division Retreat

Fri, 19 May 2023 00:00:00 +0000

ZY gave a talk titled “Decoding epigenetic regulation in early development” at the Division of Developmental Biology annual retreat.

Successful K99-to-R00 transition!

Tue, 03 Jan 2023 00:00:00 +0000

We successfully made the K99-to-R00 transition! The 3-year R00 award will support research to systemically dissect the mechanisms and functions of PcG proteins in mouse early development using the cutting-edge low-input chromatin profiling and rapid protein degradation techniques.

Chen Lab officially launched!

Mon, 02 Jan 2023 00:00:00 +0000

Chen Lab was officially launched!!